Patents / Journal Articles, Published Proceedings & Reports
Patents:
1. Northrup, M. A., and Langry, K., pH Optrode, #5,273,716, (1994).
2. Mariella, R.P., Van den Engh, G., and Northrup, M.A., Aqueous Carrier Waveguide in a Flow Cytometer , # 5,475,487, (1995).
3. Northrup, M.A., Mariella, R.P., Balch, J., and Carrano, A. Silicon-based Sleeve Devices for Chemical Reactions, # 5,589,136, (1996).
4. Benett, W.J., Krulevitch, P.A., Lee, A.P., Northrup, M.A., Folta, J.A. Miniature Plastic Gripper and Fabrication, # 5,609,601, (1997).
5. Northrup, M.A., and White, R.M., Microfabricated Reactor, # 5,639,423, (1997).
6. Northrup, M.A., Ciarlo, D., Lee, A.P., Krulevitch, P.A, Microfabricated Therapeutic Actuator Mechanisms, # 5,645,564 (1997).
7. Northrup, M.A., and White, R.M., Microfabricated Reactor, #5,646,039, (1997).
8. Lee; A.P., Northrup; M. A., Ahre; P.E., Dupuy; P.C., Polymer Micromold and Fabrication Process, # 5,658,515 (1997).
9. Northrup, M.A., and White, R.M., Microfabricated Reactor, (divisional) #5,674,742, (1997).
10. Benett; W. J., Krulevitch; P. A., Lee; A.P., Northrup; M. A., and Folta; J. A., Fabrication Method for Miniature Plastic Gripper, # 5,783,130 (1998):
11. Lee; A. P., Krulevitch; P. A., Northrup; M. A., Trevino; J.C., Micromachined Actuators/sensors for Intratubular Positioning/steering, # 5,771,902 (1998).
12. Lee; A. P., Krulevitch; P. A., Northrup; M. A., Trevino; J.C. Microvalve. # 5,819,749 (1998).
13. Northrup, M.A., Yu, C., and Raley, N. Porous Silicon Structure with High Surface Area/Specific Pore Size, # 5,882,496, (1999).
14. Lee, A.P., Northrup, M.A., Ciarlo, D, Benett, W., Krulevitch, P.A., Microfabricated Therapeutic Actuators, # 5,911,937 (1999).
15. Lee; A. P., Krulevitch; P.A., Northrup; M. A. Benett, W.J., Microbiopsy/precision cutting devices,# 5,928,161 (1999).
16. Lee; A. P., Krulevitch; P.A., Northrup; M. A., Micromachined electrical cauterizer. # 5,944,717 (1999).
17. Krulevitch; P.A., Lee; A. P., Northrup, M. A. Benett, W.J., Microfabricated Instrument for Tissue Biopsy and Analysis # 5,985,217 (1999).
18. Northrup, M.A., Yu, C., and Raley, N., Process for Forming A Porous Silicon Member in a Crystalline Silicon Member, # 6,004,450, (1999).
19. Lee; A. P., Northrup; M. A., Ciarlo; D. R., Krulevitch; P.A., Benett; W. J., Release Mechanism Utilizing Shape Memory Polymer Material, # 6,102,933 (2000).
20. Krulevitch, P. A., Lee, A.P., Northrup; M. A., Benett, W., Microfabricated instrument for tissue biopsy and analysis,# 6,319,474, ( 2001).
21. Christal, L.A., Kovacs, G.T.A., McMillan, W.A., Northrup, M.A., Petersen, K.E. Pourahmadi, F., Non-planar microstructures for manipulation of fluid samples, # 6,368,871 (2002).
22. Christal, L.A., Northrup, M.A., Petersen, K.E., McMillan, W.A., Kovacs, G.T.A., Dority, D.B., Hebert, R.T., Kintz, G.J., Multi-channel Optical Detection System, # 6,369,893 (2002).
23. Petersen, K.E., Taylor, M.T Pourahmadi, F., McMillan, W.A., Chang, R., Sakai, S.H., Ching, J., Dority, D.B., Belgrader, P., Northrup, M.A., Apparatus for analyzing a fluid sample , # 6,391,54, (2002).
24. Pourahmadi, F., McMillan, W.A., Ching, J., Chang, R., Christel, L.A., Kovacs, G.T.A., Northrup, M.A., Petersen, K.E., Integrated fluid manipulation cartridge, # 6,440,725 (2002).
25. Northrup, M.A., Hseuh, Y.T., Smith, R., Microfabricated Electrochemiluminescence Cell for Chemical Reactions, # 6,521,181 (2003).
26. Northrup, M.A., Microfabricated sleeve devices for chemical reactions, # 6,524,532(2003).
27. Chang, R., Christal, L.A., Kovacs, G.T.A., McMillan, W.A., Northrup, M.A., Petersen, K.E., Pourahmadi, F., Yuan, R., Dority, D., Heat exchanging, optically interrogated chemical reaction assembly, # 6,565,815 (2003).
28. Northrup, M. A., Temperature Control Apparatus, # 6,602.473, (2003).
29. Pourahmadi, F., McMillan, W.A., Ching, J., Chang, R., Christel, L.A., Kovacs, G.T.A., Northrup, M.A., Petersen, K.E., Device Incorporating a Microfluidic Chip for Separating Analyte from Sample # 6,664,104 (2003).
30. Pourahmadi, F., McMillan, W.A., Ching, J., Chang, R., Christel, L.A., Kovacs, G.T.A., Northrup, M.A., Petersen, K.E., Device for Lysing Cells, Spores, or Microorganisms, # 6,678,540 (2005).
31. Petersen, K.E., Taylor, M.T., Pourahmadi, F., McMillan, W.A., Chang, R., Sakai, S.H., Ching, J., Dority, D.B., Belgrader, P., Northrup, M.A., Apparatus for analyzing a fluid sample, # 6,881,541(2005).
32. McMillan, W.A., Petersen, K.E., Christel, L.A , Chang, R., Pourahmadi, F., Ching, J., Kovacs, G.T.A J., Northrup, M.A., Device and Method for Lysing Cells, Spores, or Microorgansims (2005).
33. Petersen, K.E., McMillan, W.A., Christel, L.A , Chang, R., Pourahmadi, F.,Ching, J., Kovacs, G.T.A J., Northrup, M.A., Method for Separating analyze from a Sample # 6,893,879 (2005).
34. Christel, L.A., Northrup, M.A., Petersen, K.E., McMillan, W.A, Kovacs, G.T.A., Young, S.J., Chang, R., Dority, D.B., Hebert, R.T., and Kintz, G.J., Multichannel Optical Detection System, # 6,940,598 (2005)
35. Northrup, M.A., Petersen, K.E., McMillan, W.A, Kovacs, G.T.A., Integrated Sample Analysis Device, # 6,979,424 (2005).
36. Christel, L.A ., Kovacs, G.T.A., McMillan, W.A., Northrup, M.A., Petersen, K.E., Method for Manipulation of a Fluid Sample # 7,135,144 (2006).
37. Northrup, M.A., White, R.A., Microfabricated Reactor, # 7,169,601 (2007).
38. Young, S.J., Kovacs, G.T.A., Northrup, M.A., Petersen, K.E., McMillan, W.A, Othmer, K., Christel, L.A., System and Method for Temperature Control, # 7,188,001 (2007).
39. Chang, R., Christel, L.A., Kovacs, G.T.A., McMillan, W.A., Northrup, M.A, Petersen, K.E., Pourahmadi, F., Young, S.J., Yuan, R., Apparatus and Reaction Vessel for Controlling the Temperature of a Sample, # 7,255,833 (2007).
40. Northrup, M.A., White, R.A. Microfabricated Reactor, Process for Manufacturing the Reactor, and Method of Amplification, # 7,297,313 (2007).
41. Petersen, K.E., McMillan, W.A., Christel, L.A., Chang, R., Pourahmadi, F., Ching, J., Kovacs, G.T.A. , Northrup, M.A., Method for Separating Analyze from a Sample,
42. # 7,569,346 (2009).
43. Northrup., M.A., Beeman, B.V., Benett, W.J., Hadley, D.R., Landre, P., Lehew, S.L., Krulevitch, P.A., Sleeve Reaction Chamber System., # 7,578,976 (2009).
44. Northrup, M.A., Pourahmadi, F., Yuan, B., Devitt, A.J., Integrated Airborne Substance Collection and Detection System, # 7,633,606 (2009).
45. Northrup, M.A., Pourahmadi, F., Yuan, B., Devitt, A.J., Integrated Airborne Substance Collection and Detection System, # 7,705,739 (2010).
46. Yuan, B., Northrup, M.A., Pourahmadi, F., Apparatus to Automatically Lyse A Sample, # 7,785,868 (2010).
47. Northrup, M.A., Pourahmadi, F., Yuan, B., Devitt, A.J., Integrated Airborne Substance Collection and Detection System, # 7,858,366 (2010).
48. Petersen, K.E., McMillan, W.A., Christel, L.A., Chang, R., Pourahmadi, F., Ching, J., Kovacs, G.T.A., Northrup, M.A., Method for Separating Analyte from a Sample, #7,914,994 (2010).
49. Northrup, M.A., White, R.A. Microfabricated Reactor, Process for Manufacturing the Reactor, and Method of Amplification, # 7,935,312 (2011).
50. Chang, R., Christel, L.A., Kovacs, G.T.A., McMillan, W.A., Northrup, M.A., Petersen, K.E., Pourahmadi, F., Young, S.J., Yuan, R., Dority, D. B., Thermal Cycler with Optical Detector, # 8,029,733 (2011).
51. Northrup, M.A., Apparatus and Method of Extracting and Optically Analyzing an Analyte from a Fluid-based Sample, # 8,053,214 (2011).
Journal Articles, Published Proceedings & Reports:
1. Schmidt, M. and Northrup, M. A., A Cost-Effective Instrument for Accurate Trace Element Analysis, Amer. Lab., Feb., 1986, 125-134.
2. Northrup, A., Computer-Aided Chemistry: Effective Management of Chemical Information, Bio/technology, vol 5. (5), 1987, 455-459.
3. Northrup, M. A., Stanker, L., Vanderlaan, M., and Watkins, B., Development and Characterization of a Fiber Optic Immuno-Biosensor, In Spectroscopy of Inorganic Bioactivators, T. Theophanides (Ed.), Kluwer Academic, Norwell, 1989, 229-241.
4. Northrup, M. A., Langry, K., and Angel, S. M., Stability Studies of a pH-Sensitive Polymer Matrix: Applications to Fiber Optic pH Sensors, Proceedings of SPIE Conference on Optical Fibers in Medicine V, vol. 1201, 1990, 368-374.
5. Northrup, M. A., Kulp, T.J., and Angel, S.M., Fluorescent Particle Imaging Velocimetry: Applications to Porous Media Flow, Applied Optics, vol. 30, 1991, 3034-3040.
6. Northrup, M. A., Kulp, T.J., Angel, S.M., and Finder, G.F., Determination of Velocity Vectors in Porous Media With Fluorescent Particle Image Velocimetry (FPIV), In Convective Heat and Mass Transfer in Porous Media. S. Kakac, B. Kilkis, F. Kulacki, and F. Arinc (Eds.), Kluwer Academic Pub., Dordrecht, The Netherlands, 1991, 867-881.
7. Northrup, M.A., Kulp, T.J., and Angel, S.M., Application of Fluorescent Particle Imaging to Measuring Flow in Complex Media, Analytica Chimica Acta, vol. 255, (2) 1991, 275-282.
8. Northrup, M.A., Kulp, T.J., Angel, S.M. and G.F. Pinder, Direct Measurement of Interstitial Velocity Field Variations in a Porous Medium using Fluorescent-Particle Image Velocimetry, Chemical Engineering Science, vol. 48, (1), 1993, 13-21.
9. Angel, S.M. and Northrup, M.A., Stability of a Fiber Optic pH Sensor at 100°F. Electric Power Research Institute (EPRI), Report TR-101972, 1993.
10. Northrup, M.A., Ching, M.T., White, R.M., and Watson, R.T., DNA Amplification in a Microfabricated Reaction Chamber, In Transducers ‘ 93, Seventh International Conference on Solid State Sensors and Actuators, IEEE Proceedings, Yokohama, Japan, 1993, 924-927.
11. Lee A.P., Hong K., Trevino, J., Northrup, M.A .Thin Film Conductive Polymer for Microactuator and Micromuscle Applications., Annual Meeting of the American Society of Mechanical Engineers (ASME), Chicago, Nov., 1994.
12. Krulevitch, P., Ramsey, P.B., Makoweicki, D.M., Lee, A.P., Johnson, G.C., and Northrup, M.A., Mixed Sputter Deposition of Ni-TI-Cu Shape Memory Films, in Proceedings of SMST-94, First International Conference on Shape Memory and Superelasticity, A.R. Pelton, D. Hodgson, and T. Duerig (Eds.), Nitinol Development Corp., Fremont, CA. 1995.
13. Krulevitch, P., Ramsey, P.B., Makoweicki, D.M., Lee, A.P., Johnson, G.C., and Northrup, M.A., Mixed Sputter Deposition of Ni-TI-Cu Shape Memory Films, Thin Solid Films, vol. 274, 1996, 101-105.
14. Northrup, M.A., Hills, R.F., Landre, P., Lehew, Hadley, D., Watson, R. A MEMS-based DNA Analysis System., Transducers 95, Eighth International Conference on Solid State Sensors and Actuators, IEEE Proceedings, Stockholm, Sweden, June, 1995, 764-767.
15. Hsueh, Y-T., Smith, R.L., and Northrup, M.A., A Microfabricated Electrochemiluminescence Cell for the Detection of Amplified DNA, Transducers ‘95, Eighth International Conference on Solid State Sensors and Actuators, IEEE Proceedings, Stockholm, Sweden, June, 1995, 768-771.
16. Lee, A.P., Ciarlo, D.R., Krulevitch, P.A., Lehew, S., Trevino, J., and Northrup, M.A., A Practical Microgripper by Fine Alignment, Eutectic Bonding, and SMA Actuation, Transducers ‘95, Eighth International Conference on Solid State Sensors and Actuators, IEEE, Stockholm, Sweden, June, 1995, 368-371.
17. Lee, A.P., Ciarlo, D.R., Krulevitch, P.A., Lehew, S., Trevino, J., and Northrup, M.A., A Practical Microgripper by Fine Alignment, Eutectic Bonding, and SMA Actuation, Sensors and Actuators A.SNA 054/1-3, 1996), 755-759.
18. Lee A.P., Lehew, S., Yu, C., Ciarlo, D.R., and Northrup, M.A. Selective Au-Si Eutectic Bonding for Si-Based MEMS Applications, Third International Symposium on Semiconductor Wafer Bonding, Meeting of Electrochemical Society, Reno, NV, May, 1995, 518-527.
19. P. Krulevitch, A.P. Lee, P.B. Ramsey, J. Trevino, J. Hamilton, and M.A. Northrup, Thin Film Shape Memory Alloy Microactuators, Journal of Micro-Electro-Mechanical Systems, vol. 5 (4), 1996.
20. Hsueh, Y-T., Smith, R.L., and Northrup, M.A., A Microfabricated Electrochemiluminescence Cell for the Detection of Amplified DNA, Sensors and Actuators, B33, 1996, 110-114.
21. Woolley, A.T., Hadley, D., Landre, P., deMello, A.J., Mathies, R.A. and Northrup, M.A., Functional Integration of PCR Amplification and Capillary Electrophoresis in a Microfabricated DNA Analysis Device. Analytical Chem., 68, 1996, 4081-86.
22. Northrup, M.A., Beeman, B., R.F., Hadley, D., Landre, P., Lehew, S. Integrated Miniature DNA-based Analytical Instrument In Anal. Methods and Instrumentation, Special Issue on MicroTAS, H. M. Widmer (ed) c/o Ciba Geigy, Basel, Nov. 1996, 153-157.
23. Northrup, M.A., B. Beeman, D. Hadley, P. Landre, S. Lehew, Development of a Micromachined Chemical Reaction Chamber: Application to the Polymerase Chain Reaction,” in Automation Technologies for Genome Characterization, T. J. Beugelsdijk, (Ed). J Wiley & Sons, New York, NY, 1997, Chapter 9.
24. Belgrader, P., Smith, J.K., Weedn, V.W., and Northrup, M.A., The Application of a Portable, Miniature Thermal Cycler for Human Identification., Journal of Forensic Science, 43(3), 1998, 315-119.
25. Ibrahim, M.S., Lofts, R.S., Henchal, E.A., Jahrling, P., Weedn, V.W., Northrup, M.A., and Belgrader, P. Real-time Microchip PCR for Detecting Single-Base Differences in Viral and Human DNA, Analytical Chem., 70(9), 1998, 2013-2017.
26. Northrup, M.A., D. Hadley, P. Landre, S. Lehew, J. Richards, and P. Stratton, A Miniature DNA-based Analytical Instrument Based on Micromachined Silicon Reaction Chambers, Analytical Chemistry, 70, (5) 1998, 918-922.
27. Petersen, K.E., McMillan, W.A., G.T.A. Kovacs, M.A. Northrup, L.A. Christal, and F. Pourahmadi, Toward the Next Generation Clinical Diagnostic Instruments: Scaling and New Processing Paradigms. Biomedical Microdevices, (Kluwar Academic) vol. 1, ( 1), 1998, 71-80.
28. Christel, L.A., Petersen, K., McMillan, W., Northrup, M.A. Rapid, Automated Nucleic Acid Probe Assays Using Silicon Microstructures for Nucleic Acid Concentration, Journal of Biomechanical Engineering, Vol. 211, 1998, 22-27.
29. Petersen, K., McMillan, W.A., Kovacs, G.A., Northrup, M.A., Christel, L., and Pourahmadi, The Promise of Miniaturized Clinical Diagnostic Systems”, IVD Technology, 4(4), 43-49, 1998.
30. Northrup, M.A., Christel, L., McMillan, W.A., Petersen, K., Pourahmadi, F., Western. L., and Young, S. “A New Generation of PCR Instruments and Nucleic Acid Concentration Systems” in PCR Applications, Protocols for Functional Genomics, Innis, M.A., et al (Eds), Academic, San Diego, Chapter 8. 1998.
31. Belgrader, P., Hansford, D., Kovacs, G.T.A., Kudomidi, V., Mariella, R. P., Milanovich, F., Nasarabadi, S., Okuzumi, M., and Northrup, M.A., A Minisonicator to Rapidly Disrupt Bacterial Spores for DNA Analysis, Analytical Chemistry, vol. 17 (19), 1999, 4232-4236.
32. Belgrader, P. Okuzumi, M., Pourahmadi, F., Borkholder, D.A., and Northrup, M.A., A Microfluidic Cartridge to Prepare Spores for PCR Analysis, Biosensors and Bioelectronics, vol. 14, 2000, 849-852.
33. Pourahmadi, F., Lloyd, K., Kovacs, G., Chang, R., Taylor, M., Sakai, S., Schafer, T., McMillan, W., Petersen, K., and Northrup, M. A., Versatile, Adaptable and Programmable Microfluidic Platforms for DNA Diagnostics and Drug Discovery Assays, Proceedings of the MicroTAS 2000 Symposium, May 14 - 18, , Enschede, Netherlands, 2000, 243 - 284.
34. Pourahmadi F., Taylor M., Kovacs G., Lloyd K., Sakai S., Schafer T., Helton B., Western L., Zaner .S, Ching J., McMillan B., Belgrader .P, Northrup, M.A., Toward a rapid, integrated, and fully automated DNA diagnostic assay for Chlamydia trachomatis and Neisseria gonorrhoeae. Clin Chem. vol. 46, (9), 2000, 1511-13.
35. Taylor, M.T., Belgrader, P., Furman, B.J., Pourahmadi, F., Kovacs, G.T.A., and Northrup,M.A., Lysing Bacterial Spores by Sonication Through a Flexible Interface in a Microfluidic System, Analytical Chemistry, vol. 73, ( 3), 492-496, 2001.
36. Belgrader, P., Young, S., Yuan, B., Primeau, M., Christel, L.A., Pourahmadi, F., and Northrup, M.A., A Battery-Powered Notebook Thermal Cycler for Rapid Multiplex Real-Time PCR Analysis. Analytical Chemistry, vol. 73, (2), 2001, 286-289.
37. Raisi, F., Belgrader, P., Borkholder, D.A., Herr, A.E., Kintz, G.J., Pourhamadi, F., Taylor, M.T., and Northrup, M.A., Microchip Isoelectric Focusing Using a Miniature Scanning Detection System. Electrophoresis, vol. 22, 2001, 2291-2295.
38. Taylor, M.T., Belgrader, P. Joshi, R., Kintz, G.A. and Northrup, M.A., (2001) Fully Automated Sample Preparation for Pathogen Detection Performed in a Microfluidic Cassette. In Micro Total Analysis Systems 2001, A. Van den Berg et. al., (eds.), Kluwer Academic Publishers. Netherlands, 2001.
39. Taylor, M.T., Raisi, F., Belgrader, P., Pourahmadi, F., Herr, A.E., Kintz, G.A., and Northrup, M.A., Microfluidic Bioanalysis Cartridge with Interchangeable Microchannel Separation Components. Transducers ‘01 Eurosensors XV, Munich, 2001, 1214-1217.
40. Northrup, M.A., Pourahmadi, F., Brounstein, K., Velasco, J., Yuan, B., and Belgrader, P. Autonomous, Continuously Operating Pathogen Detection System, InMicro Total Analysis Systems 2005, A. Van den Berg et. al., (eds), Kluwer Academic Publishers. Netherlands, 2005.
Review Committees, Paper Reviews, and Panels:
1. Study Section Committee (Ad Hoc), National Institutes of Health (NIH), National Center for Human Genome Research, Washington, D.C., June 17-18, 1996.
2. Panelist, Future of DNA Technology in The Criminal Justice System, National Institutes of Justice, U.S. Department of Justice, Washington, D.C., June, 14-15, 1996.
3. Co-Chairman, Chem/Bio Panel, DoD Advanced Research and Experimental Sensing (ARES) Burton Richter (Nobel Laureate, Chairman).
4. Editorial Board, Biomedical Microdevices, Kluwar Academic, 1997-present.
5. Invitee, Workshop on Micro-Chemical Systems and Their Applications, Sponsored by ARO and DARPA. June 16-18, 1998, Wash. D.C.
6. Appointed to National Academy of Sciences (NAS)/Research Council (NRC) Committee on the Future of Biotechnology for the Army. 1999.
7. Expert Witness, National Academy of Sciences (NAS) National Research Council (NRC) Committee on Biothreats for Agriculture. 2004.
8. Policy Board Member of the Center for Biochemical Optoelectronic Microsystems (CBOM), Harvard and Cornell Universities, 2001-2004.
9. Panelist, National Academy of Sciences (NAS)/Research Council (NRC) Committee on the Biological Threats to Animals and Agriculture 2001.
10. Program Reviewer, National Science Foundation of Ireland, 2003.
11. Proposal Reviewer, National Science and Engineering Research Center (NSERC), Canada, 2004.
12. Founding Member, Steering Committee Member, Chairman, Board of Directors, uTAS (microTotal Analysis Systems), Chemical and Biological Microsystem Society (CBMS).1996 - present.
1. Northrup, M. A., and Langry, K., pH Optrode, #5,273,716, (1994).
2. Mariella, R.P., Van den Engh, G., and Northrup, M.A., Aqueous Carrier Waveguide in a Flow Cytometer , # 5,475,487, (1995).
3. Northrup, M.A., Mariella, R.P., Balch, J., and Carrano, A. Silicon-based Sleeve Devices for Chemical Reactions, # 5,589,136, (1996).
4. Benett, W.J., Krulevitch, P.A., Lee, A.P., Northrup, M.A., Folta, J.A. Miniature Plastic Gripper and Fabrication, # 5,609,601, (1997).
5. Northrup, M.A., and White, R.M., Microfabricated Reactor, # 5,639,423, (1997).
6. Northrup, M.A., Ciarlo, D., Lee, A.P., Krulevitch, P.A, Microfabricated Therapeutic Actuator Mechanisms, # 5,645,564 (1997).
7. Northrup, M.A., and White, R.M., Microfabricated Reactor, #5,646,039, (1997).
8. Lee; A.P., Northrup; M. A., Ahre; P.E., Dupuy; P.C., Polymer Micromold and Fabrication Process, # 5,658,515 (1997).
9. Northrup, M.A., and White, R.M., Microfabricated Reactor, (divisional) #5,674,742, (1997).
10. Benett; W. J., Krulevitch; P. A., Lee; A.P., Northrup; M. A., and Folta; J. A., Fabrication Method for Miniature Plastic Gripper, # 5,783,130 (1998):
11. Lee; A. P., Krulevitch; P. A., Northrup; M. A., Trevino; J.C., Micromachined Actuators/sensors for Intratubular Positioning/steering, # 5,771,902 (1998).
12. Lee; A. P., Krulevitch; P. A., Northrup; M. A., Trevino; J.C. Microvalve. # 5,819,749 (1998).
13. Northrup, M.A., Yu, C., and Raley, N. Porous Silicon Structure with High Surface Area/Specific Pore Size, # 5,882,496, (1999).
14. Lee, A.P., Northrup, M.A., Ciarlo, D, Benett, W., Krulevitch, P.A., Microfabricated Therapeutic Actuators, # 5,911,937 (1999).
15. Lee; A. P., Krulevitch; P.A., Northrup; M. A. Benett, W.J., Microbiopsy/precision cutting devices,# 5,928,161 (1999).
16. Lee; A. P., Krulevitch; P.A., Northrup; M. A., Micromachined electrical cauterizer. # 5,944,717 (1999).
17. Krulevitch; P.A., Lee; A. P., Northrup, M. A. Benett, W.J., Microfabricated Instrument for Tissue Biopsy and Analysis # 5,985,217 (1999).
18. Northrup, M.A., Yu, C., and Raley, N., Process for Forming A Porous Silicon Member in a Crystalline Silicon Member, # 6,004,450, (1999).
19. Lee; A. P., Northrup; M. A., Ciarlo; D. R., Krulevitch; P.A., Benett; W. J., Release Mechanism Utilizing Shape Memory Polymer Material, # 6,102,933 (2000).
20. Krulevitch, P. A., Lee, A.P., Northrup; M. A., Benett, W., Microfabricated instrument for tissue biopsy and analysis,# 6,319,474, ( 2001).
21. Christal, L.A., Kovacs, G.T.A., McMillan, W.A., Northrup, M.A., Petersen, K.E. Pourahmadi, F., Non-planar microstructures for manipulation of fluid samples, # 6,368,871 (2002).
22. Christal, L.A., Northrup, M.A., Petersen, K.E., McMillan, W.A., Kovacs, G.T.A., Dority, D.B., Hebert, R.T., Kintz, G.J., Multi-channel Optical Detection System, # 6,369,893 (2002).
23. Petersen, K.E., Taylor, M.T Pourahmadi, F., McMillan, W.A., Chang, R., Sakai, S.H., Ching, J., Dority, D.B., Belgrader, P., Northrup, M.A., Apparatus for analyzing a fluid sample , # 6,391,54, (2002).
24. Pourahmadi, F., McMillan, W.A., Ching, J., Chang, R., Christel, L.A., Kovacs, G.T.A., Northrup, M.A., Petersen, K.E., Integrated fluid manipulation cartridge, # 6,440,725 (2002).
25. Northrup, M.A., Hseuh, Y.T., Smith, R., Microfabricated Electrochemiluminescence Cell for Chemical Reactions, # 6,521,181 (2003).
26. Northrup, M.A., Microfabricated sleeve devices for chemical reactions, # 6,524,532(2003).
27. Chang, R., Christal, L.A., Kovacs, G.T.A., McMillan, W.A., Northrup, M.A., Petersen, K.E., Pourahmadi, F., Yuan, R., Dority, D., Heat exchanging, optically interrogated chemical reaction assembly, # 6,565,815 (2003).
28. Northrup, M. A., Temperature Control Apparatus, # 6,602.473, (2003).
29. Pourahmadi, F., McMillan, W.A., Ching, J., Chang, R., Christel, L.A., Kovacs, G.T.A., Northrup, M.A., Petersen, K.E., Device Incorporating a Microfluidic Chip for Separating Analyte from Sample # 6,664,104 (2003).
30. Pourahmadi, F., McMillan, W.A., Ching, J., Chang, R., Christel, L.A., Kovacs, G.T.A., Northrup, M.A., Petersen, K.E., Device for Lysing Cells, Spores, or Microorganisms, # 6,678,540 (2005).
31. Petersen, K.E., Taylor, M.T., Pourahmadi, F., McMillan, W.A., Chang, R., Sakai, S.H., Ching, J., Dority, D.B., Belgrader, P., Northrup, M.A., Apparatus for analyzing a fluid sample, # 6,881,541(2005).
32. McMillan, W.A., Petersen, K.E., Christel, L.A , Chang, R., Pourahmadi, F., Ching, J., Kovacs, G.T.A J., Northrup, M.A., Device and Method for Lysing Cells, Spores, or Microorgansims (2005).
33. Petersen, K.E., McMillan, W.A., Christel, L.A , Chang, R., Pourahmadi, F.,Ching, J., Kovacs, G.T.A J., Northrup, M.A., Method for Separating analyze from a Sample # 6,893,879 (2005).
34. Christel, L.A., Northrup, M.A., Petersen, K.E., McMillan, W.A, Kovacs, G.T.A., Young, S.J., Chang, R., Dority, D.B., Hebert, R.T., and Kintz, G.J., Multichannel Optical Detection System, # 6,940,598 (2005)
35. Northrup, M.A., Petersen, K.E., McMillan, W.A, Kovacs, G.T.A., Integrated Sample Analysis Device, # 6,979,424 (2005).
36. Christel, L.A ., Kovacs, G.T.A., McMillan, W.A., Northrup, M.A., Petersen, K.E., Method for Manipulation of a Fluid Sample # 7,135,144 (2006).
37. Northrup, M.A., White, R.A., Microfabricated Reactor, # 7,169,601 (2007).
38. Young, S.J., Kovacs, G.T.A., Northrup, M.A., Petersen, K.E., McMillan, W.A, Othmer, K., Christel, L.A., System and Method for Temperature Control, # 7,188,001 (2007).
39. Chang, R., Christel, L.A., Kovacs, G.T.A., McMillan, W.A., Northrup, M.A, Petersen, K.E., Pourahmadi, F., Young, S.J., Yuan, R., Apparatus and Reaction Vessel for Controlling the Temperature of a Sample, # 7,255,833 (2007).
40. Northrup, M.A., White, R.A. Microfabricated Reactor, Process for Manufacturing the Reactor, and Method of Amplification, # 7,297,313 (2007).
41. Petersen, K.E., McMillan, W.A., Christel, L.A., Chang, R., Pourahmadi, F., Ching, J., Kovacs, G.T.A. , Northrup, M.A., Method for Separating Analyze from a Sample,
42. # 7,569,346 (2009).
43. Northrup., M.A., Beeman, B.V., Benett, W.J., Hadley, D.R., Landre, P., Lehew, S.L., Krulevitch, P.A., Sleeve Reaction Chamber System., # 7,578,976 (2009).
44. Northrup, M.A., Pourahmadi, F., Yuan, B., Devitt, A.J., Integrated Airborne Substance Collection and Detection System, # 7,633,606 (2009).
45. Northrup, M.A., Pourahmadi, F., Yuan, B., Devitt, A.J., Integrated Airborne Substance Collection and Detection System, # 7,705,739 (2010).
46. Yuan, B., Northrup, M.A., Pourahmadi, F., Apparatus to Automatically Lyse A Sample, # 7,785,868 (2010).
47. Northrup, M.A., Pourahmadi, F., Yuan, B., Devitt, A.J., Integrated Airborne Substance Collection and Detection System, # 7,858,366 (2010).
48. Petersen, K.E., McMillan, W.A., Christel, L.A., Chang, R., Pourahmadi, F., Ching, J., Kovacs, G.T.A., Northrup, M.A., Method for Separating Analyte from a Sample, #7,914,994 (2010).
49. Northrup, M.A., White, R.A. Microfabricated Reactor, Process for Manufacturing the Reactor, and Method of Amplification, # 7,935,312 (2011).
50. Chang, R., Christel, L.A., Kovacs, G.T.A., McMillan, W.A., Northrup, M.A., Petersen, K.E., Pourahmadi, F., Young, S.J., Yuan, R., Dority, D. B., Thermal Cycler with Optical Detector, # 8,029,733 (2011).
51. Northrup, M.A., Apparatus and Method of Extracting and Optically Analyzing an Analyte from a Fluid-based Sample, # 8,053,214 (2011).
Journal Articles, Published Proceedings & Reports:
1. Schmidt, M. and Northrup, M. A., A Cost-Effective Instrument for Accurate Trace Element Analysis, Amer. Lab., Feb., 1986, 125-134.
2. Northrup, A., Computer-Aided Chemistry: Effective Management of Chemical Information, Bio/technology, vol 5. (5), 1987, 455-459.
3. Northrup, M. A., Stanker, L., Vanderlaan, M., and Watkins, B., Development and Characterization of a Fiber Optic Immuno-Biosensor, In Spectroscopy of Inorganic Bioactivators, T. Theophanides (Ed.), Kluwer Academic, Norwell, 1989, 229-241.
4. Northrup, M. A., Langry, K., and Angel, S. M., Stability Studies of a pH-Sensitive Polymer Matrix: Applications to Fiber Optic pH Sensors, Proceedings of SPIE Conference on Optical Fibers in Medicine V, vol. 1201, 1990, 368-374.
5. Northrup, M. A., Kulp, T.J., and Angel, S.M., Fluorescent Particle Imaging Velocimetry: Applications to Porous Media Flow, Applied Optics, vol. 30, 1991, 3034-3040.
6. Northrup, M. A., Kulp, T.J., Angel, S.M., and Finder, G.F., Determination of Velocity Vectors in Porous Media With Fluorescent Particle Image Velocimetry (FPIV), In Convective Heat and Mass Transfer in Porous Media. S. Kakac, B. Kilkis, F. Kulacki, and F. Arinc (Eds.), Kluwer Academic Pub., Dordrecht, The Netherlands, 1991, 867-881.
7. Northrup, M.A., Kulp, T.J., and Angel, S.M., Application of Fluorescent Particle Imaging to Measuring Flow in Complex Media, Analytica Chimica Acta, vol. 255, (2) 1991, 275-282.
8. Northrup, M.A., Kulp, T.J., Angel, S.M. and G.F. Pinder, Direct Measurement of Interstitial Velocity Field Variations in a Porous Medium using Fluorescent-Particle Image Velocimetry, Chemical Engineering Science, vol. 48, (1), 1993, 13-21.
9. Angel, S.M. and Northrup, M.A., Stability of a Fiber Optic pH Sensor at 100°F. Electric Power Research Institute (EPRI), Report TR-101972, 1993.
10. Northrup, M.A., Ching, M.T., White, R.M., and Watson, R.T., DNA Amplification in a Microfabricated Reaction Chamber, In Transducers ‘ 93, Seventh International Conference on Solid State Sensors and Actuators, IEEE Proceedings, Yokohama, Japan, 1993, 924-927.
11. Lee A.P., Hong K., Trevino, J., Northrup, M.A .Thin Film Conductive Polymer for Microactuator and Micromuscle Applications., Annual Meeting of the American Society of Mechanical Engineers (ASME), Chicago, Nov., 1994.
12. Krulevitch, P., Ramsey, P.B., Makoweicki, D.M., Lee, A.P., Johnson, G.C., and Northrup, M.A., Mixed Sputter Deposition of Ni-TI-Cu Shape Memory Films, in Proceedings of SMST-94, First International Conference on Shape Memory and Superelasticity, A.R. Pelton, D. Hodgson, and T. Duerig (Eds.), Nitinol Development Corp., Fremont, CA. 1995.
13. Krulevitch, P., Ramsey, P.B., Makoweicki, D.M., Lee, A.P., Johnson, G.C., and Northrup, M.A., Mixed Sputter Deposition of Ni-TI-Cu Shape Memory Films, Thin Solid Films, vol. 274, 1996, 101-105.
14. Northrup, M.A., Hills, R.F., Landre, P., Lehew, Hadley, D., Watson, R. A MEMS-based DNA Analysis System., Transducers 95, Eighth International Conference on Solid State Sensors and Actuators, IEEE Proceedings, Stockholm, Sweden, June, 1995, 764-767.
15. Hsueh, Y-T., Smith, R.L., and Northrup, M.A., A Microfabricated Electrochemiluminescence Cell for the Detection of Amplified DNA, Transducers ‘95, Eighth International Conference on Solid State Sensors and Actuators, IEEE Proceedings, Stockholm, Sweden, June, 1995, 768-771.
16. Lee, A.P., Ciarlo, D.R., Krulevitch, P.A., Lehew, S., Trevino, J., and Northrup, M.A., A Practical Microgripper by Fine Alignment, Eutectic Bonding, and SMA Actuation, Transducers ‘95, Eighth International Conference on Solid State Sensors and Actuators, IEEE, Stockholm, Sweden, June, 1995, 368-371.
17. Lee, A.P., Ciarlo, D.R., Krulevitch, P.A., Lehew, S., Trevino, J., and Northrup, M.A., A Practical Microgripper by Fine Alignment, Eutectic Bonding, and SMA Actuation, Sensors and Actuators A.SNA 054/1-3, 1996), 755-759.
18. Lee A.P., Lehew, S., Yu, C., Ciarlo, D.R., and Northrup, M.A. Selective Au-Si Eutectic Bonding for Si-Based MEMS Applications, Third International Symposium on Semiconductor Wafer Bonding, Meeting of Electrochemical Society, Reno, NV, May, 1995, 518-527.
19. P. Krulevitch, A.P. Lee, P.B. Ramsey, J. Trevino, J. Hamilton, and M.A. Northrup, Thin Film Shape Memory Alloy Microactuators, Journal of Micro-Electro-Mechanical Systems, vol. 5 (4), 1996.
20. Hsueh, Y-T., Smith, R.L., and Northrup, M.A., A Microfabricated Electrochemiluminescence Cell for the Detection of Amplified DNA, Sensors and Actuators, B33, 1996, 110-114.
21. Woolley, A.T., Hadley, D., Landre, P., deMello, A.J., Mathies, R.A. and Northrup, M.A., Functional Integration of PCR Amplification and Capillary Electrophoresis in a Microfabricated DNA Analysis Device. Analytical Chem., 68, 1996, 4081-86.
22. Northrup, M.A., Beeman, B., R.F., Hadley, D., Landre, P., Lehew, S. Integrated Miniature DNA-based Analytical Instrument In Anal. Methods and Instrumentation, Special Issue on MicroTAS, H. M. Widmer (ed) c/o Ciba Geigy, Basel, Nov. 1996, 153-157.
23. Northrup, M.A., B. Beeman, D. Hadley, P. Landre, S. Lehew, Development of a Micromachined Chemical Reaction Chamber: Application to the Polymerase Chain Reaction,” in Automation Technologies for Genome Characterization, T. J. Beugelsdijk, (Ed). J Wiley & Sons, New York, NY, 1997, Chapter 9.
24. Belgrader, P., Smith, J.K., Weedn, V.W., and Northrup, M.A., The Application of a Portable, Miniature Thermal Cycler for Human Identification., Journal of Forensic Science, 43(3), 1998, 315-119.
25. Ibrahim, M.S., Lofts, R.S., Henchal, E.A., Jahrling, P., Weedn, V.W., Northrup, M.A., and Belgrader, P. Real-time Microchip PCR for Detecting Single-Base Differences in Viral and Human DNA, Analytical Chem., 70(9), 1998, 2013-2017.
26. Northrup, M.A., D. Hadley, P. Landre, S. Lehew, J. Richards, and P. Stratton, A Miniature DNA-based Analytical Instrument Based on Micromachined Silicon Reaction Chambers, Analytical Chemistry, 70, (5) 1998, 918-922.
27. Petersen, K.E., McMillan, W.A., G.T.A. Kovacs, M.A. Northrup, L.A. Christal, and F. Pourahmadi, Toward the Next Generation Clinical Diagnostic Instruments: Scaling and New Processing Paradigms. Biomedical Microdevices, (Kluwar Academic) vol. 1, ( 1), 1998, 71-80.
28. Christel, L.A., Petersen, K., McMillan, W., Northrup, M.A. Rapid, Automated Nucleic Acid Probe Assays Using Silicon Microstructures for Nucleic Acid Concentration, Journal of Biomechanical Engineering, Vol. 211, 1998, 22-27.
29. Petersen, K., McMillan, W.A., Kovacs, G.A., Northrup, M.A., Christel, L., and Pourahmadi, The Promise of Miniaturized Clinical Diagnostic Systems”, IVD Technology, 4(4), 43-49, 1998.
30. Northrup, M.A., Christel, L., McMillan, W.A., Petersen, K., Pourahmadi, F., Western. L., and Young, S. “A New Generation of PCR Instruments and Nucleic Acid Concentration Systems” in PCR Applications, Protocols for Functional Genomics, Innis, M.A., et al (Eds), Academic, San Diego, Chapter 8. 1998.
31. Belgrader, P., Hansford, D., Kovacs, G.T.A., Kudomidi, V., Mariella, R. P., Milanovich, F., Nasarabadi, S., Okuzumi, M., and Northrup, M.A., A Minisonicator to Rapidly Disrupt Bacterial Spores for DNA Analysis, Analytical Chemistry, vol. 17 (19), 1999, 4232-4236.
32. Belgrader, P. Okuzumi, M., Pourahmadi, F., Borkholder, D.A., and Northrup, M.A., A Microfluidic Cartridge to Prepare Spores for PCR Analysis, Biosensors and Bioelectronics, vol. 14, 2000, 849-852.
33. Pourahmadi, F., Lloyd, K., Kovacs, G., Chang, R., Taylor, M., Sakai, S., Schafer, T., McMillan, W., Petersen, K., and Northrup, M. A., Versatile, Adaptable and Programmable Microfluidic Platforms for DNA Diagnostics and Drug Discovery Assays, Proceedings of the MicroTAS 2000 Symposium, May 14 - 18, , Enschede, Netherlands, 2000, 243 - 284.
34. Pourahmadi F., Taylor M., Kovacs G., Lloyd K., Sakai S., Schafer T., Helton B., Western L., Zaner .S, Ching J., McMillan B., Belgrader .P, Northrup, M.A., Toward a rapid, integrated, and fully automated DNA diagnostic assay for Chlamydia trachomatis and Neisseria gonorrhoeae. Clin Chem. vol. 46, (9), 2000, 1511-13.
35. Taylor, M.T., Belgrader, P., Furman, B.J., Pourahmadi, F., Kovacs, G.T.A., and Northrup,M.A., Lysing Bacterial Spores by Sonication Through a Flexible Interface in a Microfluidic System, Analytical Chemistry, vol. 73, ( 3), 492-496, 2001.
36. Belgrader, P., Young, S., Yuan, B., Primeau, M., Christel, L.A., Pourahmadi, F., and Northrup, M.A., A Battery-Powered Notebook Thermal Cycler for Rapid Multiplex Real-Time PCR Analysis. Analytical Chemistry, vol. 73, (2), 2001, 286-289.
37. Raisi, F., Belgrader, P., Borkholder, D.A., Herr, A.E., Kintz, G.J., Pourhamadi, F., Taylor, M.T., and Northrup, M.A., Microchip Isoelectric Focusing Using a Miniature Scanning Detection System. Electrophoresis, vol. 22, 2001, 2291-2295.
38. Taylor, M.T., Belgrader, P. Joshi, R., Kintz, G.A. and Northrup, M.A., (2001) Fully Automated Sample Preparation for Pathogen Detection Performed in a Microfluidic Cassette. In Micro Total Analysis Systems 2001, A. Van den Berg et. al., (eds.), Kluwer Academic Publishers. Netherlands, 2001.
39. Taylor, M.T., Raisi, F., Belgrader, P., Pourahmadi, F., Herr, A.E., Kintz, G.A., and Northrup, M.A., Microfluidic Bioanalysis Cartridge with Interchangeable Microchannel Separation Components. Transducers ‘01 Eurosensors XV, Munich, 2001, 1214-1217.
40. Northrup, M.A., Pourahmadi, F., Brounstein, K., Velasco, J., Yuan, B., and Belgrader, P. Autonomous, Continuously Operating Pathogen Detection System, InMicro Total Analysis Systems 2005, A. Van den Berg et. al., (eds), Kluwer Academic Publishers. Netherlands, 2005.
Review Committees, Paper Reviews, and Panels:
1. Study Section Committee (Ad Hoc), National Institutes of Health (NIH), National Center for Human Genome Research, Washington, D.C., June 17-18, 1996.
2. Panelist, Future of DNA Technology in The Criminal Justice System, National Institutes of Justice, U.S. Department of Justice, Washington, D.C., June, 14-15, 1996.
3. Co-Chairman, Chem/Bio Panel, DoD Advanced Research and Experimental Sensing (ARES) Burton Richter (Nobel Laureate, Chairman).
4. Editorial Board, Biomedical Microdevices, Kluwar Academic, 1997-present.
5. Invitee, Workshop on Micro-Chemical Systems and Their Applications, Sponsored by ARO and DARPA. June 16-18, 1998, Wash. D.C.
6. Appointed to National Academy of Sciences (NAS)/Research Council (NRC) Committee on the Future of Biotechnology for the Army. 1999.
7. Expert Witness, National Academy of Sciences (NAS) National Research Council (NRC) Committee on Biothreats for Agriculture. 2004.
8. Policy Board Member of the Center for Biochemical Optoelectronic Microsystems (CBOM), Harvard and Cornell Universities, 2001-2004.
9. Panelist, National Academy of Sciences (NAS)/Research Council (NRC) Committee on the Biological Threats to Animals and Agriculture 2001.
10. Program Reviewer, National Science Foundation of Ireland, 2003.
11. Proposal Reviewer, National Science and Engineering Research Center (NSERC), Canada, 2004.
12. Founding Member, Steering Committee Member, Chairman, Board of Directors, uTAS (microTotal Analysis Systems), Chemical and Biological Microsystem Society (CBMS).1996 - present.